Gellan gum-based hydrogel containing nanocapsules for vaginal indole-3-carbinol delivery in trichomoniasis treatment. | Semantic Scholar (2025)

A vaginal hydrogel containing PhSe2-loaded Eudragit® RS100 and coconut oil nanocapsules and chorioallantoic membrane method indicated the absence of hemorrhage, coagulation, or lysis, suggesting this compound could be a promising alternative for the treatment of trichomoniasis.

The combination of karaya and gellan gum in bilayer films that contain nanoencapsulated DIM has demonstrated potential in the topical treatment of melanoma and could serve as a viable option for administering DIM for cutaneous melanoma therapy.

The present study demonstrated the feasibility of preparing HGs with LBG and the formulation with the highest polymer concentration was the most promising to transport active ingredients through the skin.

Data suggest that itself gellan gum/pullulan bilayer film might attenuate the effects induced by DNCB, acting together with silibinin-loaded nanocapsules, which protected the skin from oxidative damage, improving the therapeutic effect in this AD-model.

HG-NK provided a significant reduction in paw edema and inflammatory markers and promoted greater permeation of KET across the skin, highlighting its potent anti-inflammatory effects and potential as a promising therapeutic strategy for managing RA.

HG-NC-I3C exhibited an anti-inflammatory effect, reduced oxidative damage, and increased antioxidant defense in decreasing acute inflammation and oxidative damage in wounds in a rat model of skin wounds.

The study suggests that nanostructured hydrogel containing a reduced effective dose of dexamethasone could be a promising therapeutic alternative to treat inflammatory disorders with reduced or absent adverse effects.

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The results confirmed the ability of nanoparticle-based hydrogels to affect viral attachment, impede penetration and cell-to-cell transmission, although profound differences in the activity evoked by tested preparations toward HSV-1 and HSv-2 were noted.

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